Prime Minister Boris Johnson is to host a press conference from Downing Street to give the nation a coronavirus update on Tuesday afternoon.
Mr Johnson will take to the podium to update the UK on coronavirus restrictions, Tier Three in Manchester, the latest statistics and the ongoing call for a national lockdown.
Mr Johnson’s statement comes on the day he set a deadline for Greater Manchester to move into Tier Three – the highest level of coronavirus restrictions.
And it comes as circuit-breaker lockdowns begin in Wales and Northern Ireland – with shops, pubs hospitality, leisure and schools closed; travel banned and people told to work from home.
There are also fears Tier Three restrictions could be imposed across the North East, North West and Midlands – following restrictions imposed in Liverpool and Lancashire.
Scotland is to unveil new restrictions on the hospitality sector on Wednesday.
Mr Johnson will host the press conference from 5pm and will be joined by Professor Jonathan Van-Tam, England’s deputy chief medical officer, and NHS England’s national medical director Prof Stephen Powis.
It comes as an expert has said England’s coronavirus restrictions tier system is “the worst of all worlds”.
Stephen Reicher, professor of social psychology at the University of St Andrews, told the All-Party Parliamentary Group on Coronavirus that the three-tier approach was a “good idea in principle” if it provided clarity and equity.
However, Prof Reicher, who is also a member of Sage, said there was a lack of clarity over what criteria was being used to place areas in different tiers, with variations of measures even within certain tiers.
He said: “So we have the worst of all worlds, we have a system where there is no sense of clarity. There is a growing sense of inequity and resistance.”
Prof Reicher warned if resistance was “politicised” it could risk bringing “polarisation”, as seen in the United States.
He added: “A tier system isn’t bad in and of itself, the way it’s been applied I think has been disastrous and is leading to political paralysis when we need action really quickly because infections are spiking.”