Many victims are feared after an airplane carrying more than 100 passengers and crew crashed into homes shortly after the pilot reportedly notified Air Traffic Control of a technical failure.
The Pakistan International Airlines jet was on its last approach at Karachi Airport when it crashed in a residential area near Model Colony and disappeared from the radar.
A number of houses were damaged or destroyed and a major rescue operation was carried out to rescue survivors.
A civil aviation authority spokesperson told local media that 99 passengers and eight crew members were on board the Airbus A320.
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Photos and video show a huge cloud of black smoke pouring into the air after the crash, which happened around 2:45 p.m. local time on Friday.
Flight PK8303 was on a domestic trip from Lahore.
Civil Aviation Authority (CAA) sources said the captain had reported a technical malfunction and the plan had disappeared from the radar shortly before landing at Karachi airport, 24 News reported.
CAA sources told News One that communication with the plane was cut off one minute before it was due to land.
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