In one of his monthly “prayer intentions”, which has been shared on YouTube, the pope suggested he was concerned about technology.
The message implied AI and robots could further increase inequalities.
He said AI was “at the heart of the epochal change we are experiencing.”
He also acknowledged that robotics had the power to change the world in a positive way.
However, they will only change the world for the better if harnessed correctly, reports The verge.
The pope said: “Indeed, if technological progress increases inequalities, it is not true progress.
“Future advances should be orientated towards respecting the dignity of the person.”
It comes as earlier this year, Pope Francis supported a call by IBM and Microsoft to work on the ethics of AI.
The leaders and the pope discussed “human–centred” ways of designing AI, reports BBC.
Microsoft president Brad Smith said: “I think the world needs people from different places to come together.”
He also said: “I think it’s a challenging time because there is so much polarisation in so many parts of the world.”
“We need people who can work to close the gaps that divide us – so in some ways I look at the Catholic Church, I look at a company like Microsoft, and I say why not?”
In September, Pope Francis claimed that gossiping is a “plague worse than Covid” that is seeking to divide the church.
Francis used his weekly blessing to go on, at some length, about whispers within church communities and the Vatican.
Without going into specifics, he said the devil is “the biggest gossiper” who is seeking to divide the church with lies.
The Pope told worshippers: “Please, brothers and sisters, let’s make an effort not to gossip. Gossiping is a worse plague than COVID. Worse. Let’s make a big effort – no gossiping!”