Experts are warning that plans to mass test the whole population for Covid-19 could “fail miserably”.
The Operation Moonshot scheme could cost the Government a reported £100 billion.
However, academics have raised serious concerns about the project – and about the effectiveness of the tests.
The scientists say the proposals have been developed without the UK National Screening Committee, the body that advises the Government on screening strategy.
Moreover, tests for Covid-19 are not perfect and could produce false positives and miss detecting some new cases, they are warning.
The experts say relying on rapid tests that give a result in minutes could mean that a high proportion of cases are missed with false negative results.
One expert said the Innova lateral flow tests being used in the Liverpool mass screening pilot detect 73 per cent of cases when patients are tested on a site with experienced research nurses.
But this falls to 57 per cent among self-trained staff members at a testing centre.
An evaluation by Oxford University and Public Health England workers concluded that the test has an overall sensitivity of 76.8 per cent – although it detects almost all cases among patients with a high viral load.
Dominic Cummings will reportedly continue to work on Operation Moonshot while working from home until his permanent departure from Downing Street.
But Dr Angela Raffle, consultant in public health and honorary senior lecturer at the University of Bristol, said: “When I learned of the Moonshot proposals this seemed to me to be the most unethical proposal for use of public funds or for screening that I’d ever seen.”
She has raised concerns about several problems.
These include the short period of time in which people need to be tested; fears that the planning and infrastructure is not in place; the cost; and worries that the proposals have not been scrutinised by screening experts.
“It worries me that ministers or whoever can wake up one morning saying, ‘let’s spend £100 billion on this’ and not have it scrutinised,” she said.
“It would be like building a Channel Tunnel without asking civil engineers to look at the plans.
“Even if it could work the way we’re going about it is destined to make sure it will fail miserably.”
She added the proposals could also lead to a “chaotic scramble to have tests, which we don’t know will bring any benefit”.
Academics are urging the Prime Minister to use the so-called post-Cummings Downing Street reset to review the programme in a “sensible and rational way”.
Scientists have also issued a warning to students getting tested this Christmas.
They say those tested before being allowed to return home for Christmas must be told clearly that a negative test result “reduces the risk” they are taking Covid-19 back home to their families, but does not eliminate it.
In addition, they say mass testing of the whole population before Christmas could see 400,000 unnecessarily self-isolating during the holiday period.
Allyson Pollock, clinical professor of public health at the University of Newcastle, called for the Moonshot programme to be paused while its cost effectiveness is established.
She added: “It’s really important to understand that none of these tests are tests of infectiousness.
“And that is one of the myths that’s being propagated, and was being propagated in Liverpool – that you could have your test in the morning and if you were negative you could go about your business or go to funerals or go to the nursing homes, and you’ll be fine.”
She added: “There has been far too little scrutiny and oversight of these contracts, and they’ve been bypassing the procurement process.
“And there’s been little evidence to show that they are value for money.”
Prof Pollock continued: “We have to think very carefully before we spend a hundred billion pounds on programmes that we do not know and have no evidence that they will work.
“The evidence for screening is not there. The evidence around the tests is poor and weak at the moment, and needs to be improved. And we’re arguing the Moonshot programme really should be paused until the cost effectiveness and the value for money of any of these programmes is well established.”
When asked if people would safely be able to see their families at Christmas if they had a test, Jon Deeks, professor of biostatistics at the University of Birmingham said: “We would end up with 400,000 people in the country getting false positive results.
“So their Christmas would then be in lockdown wrongly.
“And as we saw, the test will only pick up people when they’re in their most viral point and probably the test results or are applicable for one day.
“It certainly isn’t a suitable way to make sure we have a safe Christmas.”
He said the concept of “test and release” – whereby someone could behave in a normal way after a negative result – was “dangerous”.
Prof Pollock added that the reset would be a good opportunity to “review some of these big strategic programmes”.
“It’s a really good chance to start anew and to revisit all this in a very sensible and rational way,” she added.
“And to take advice from the experts, which is something that the Government has failed to do over Operation Moonshot.”
Prof Deeks added that students should see a negative test result as a “risk reduction”.
“You still have to think you’ve potentially got it,” he said.
“So it’s not going to rule out the fact that they’re taking Covid back home – it will reduce it, but it doesn’t stop it.”